Announcement

Collapse
No announcement yet.

Q and A with Seth Roberts (Author of ANABOLIC PHARMACOLOGY)

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Q and A with Seth Roberts (Author of ANABOLIC PHARMACOLOGY)

    anabolic_pharm_book_large.jpg

    Anabolic Pharmacology Reference Book by Seth Roberts
    Seth Roberts’ ANABOLIC PHARMACOLOGY is the most advanced reference text on the market because it is the only book of its kind written by a former pharmaceutical scientist. Ten years in the making, this is not a bunch of re-hashed out-of-date information but a brand new look into the action of anabolic hormones. Find out how these drugs work as this text delves into the receptor and non-receptor mediated actions of anabolics.

    ANABOLIC PHARMACOLOGY introduces new mechanisms of action that are unknown to the underground community. Also found inside are experimental and exotic compounds that are not discussed in any other text or on-line source.

    ANABOLIC PHARMACOLOGY turns Bro-lore upside down by explaining some of the scientific truth behind the anecdotal experience as explained by a real scientist who has worked for over a decade in the pharmaceutical industry; not some armchair expert. This book discusses an advanced topic in a step-wise fashion. Information is laid out in a progression giving you the basic information you need to understand advanced concepts.

    You probably know about aromatase and 5-alpha reductase but do you know about:
    Enzyme that dramatically influences the results of a cycle?
    What effect does injection volume and location have on the half-life of injectable AAS?
    What is the difference between water retention and edema and what causes them?
    This book has information that you won’t find anywhere else…
    From understanding blood tests to learning about the role of active metabolites, ANABOLIC PHARMACOLOGY covers every aspect of the physiology, pharmacology and pharmacokinetics of anabolics.

    Table of Contents:
    I. Introduction
    II. Bro’lore
    III. Steroids and the Law
    IV. Basic Chemistry
    V. Units and Stoichiometry
    VI. Anabolism/Catabolism
    VII. Steroid Hormone Superfamily
    VIII. Enzymes
    IX. Binding Proteins
    X. Crossover
    XI. Synthetic AAS
    XII. Counterfeits
    XIII. Exogenous Administration of AAS
    XIV. Spot Injections
    XV. Side Effects
    XVI. Background Research
    XVII. Selective Androgen Receptor Modulators
    XVIII. Availability of AAS
    XIX. Expectations
    XX. AAS Profiles
    XXI. Ancillary Medication profiles
    XXII. Pharmacokinetics
    XXIII. Drug Metabolism
    XXIV. Stacking
    XXV. Dosing
    XXVI. Stacks/Cycles
    XXVII. Post-Cycle Therapy
    XXVIII. Peptide Hormones
    XXIX. Health Monitoring

    Seth Roberts is a former pharmaceutical research scientist with over 10 years of pharmacological research in the discovery and development of novel therapeutics. Seth’s new book ANABOLIC PHARMACOLOGY is available now at www.LGSciences.com and www.NutraPlanet.com. [ Seth Roberts, 2009. All rights reserved. For informational purposes only, not to be considered as medical advice or an endorsement of the use of illegal substances.]

    Got a question for Seth? Ask him here...
    Last edited by Robbie Durand; May 31st, 2009, 07:08 PM.

  • #2
    I am happy to be here at Muscular Development. Hopefully we can get some good discussions going.
    ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

    Comment


    • #3
      Seth's First Article in MD

      Anabolic Pharmacology
      By Seth Roberts


      Pharmacology is the study of drugs and their effects. Anabolic pharmacology is the study of drugs that have a growth-promoting effect in muscle. This column will explore anabolic pharmacology by profiling a different anabolic drug and its effects each month. The focus of discussion this month will be the anabolic androgenic steroid, fluoxymesterone.


      Fluoxymesterone is more popularly known by its brand name, Halotestin or Halo for short. Halotestin is actually derived from cortisol (a glucocorticoid) and as you can see from its structure, shares the C-11 hydroxyl (OH) group with cortisol-like steroids. The binding affinity of halotestin for the androgen receptor is very low but contrary to popular belief, its androgenic effects are still mediated through the androgen receptor.1 Halotestin cannot be converted to estrogenic metabolites, but is converted to a more potent 5-alpha reduced form.2 The half-life of the parent compound is a little more than 9 hours, but the presence of active metabolites (such as the 5-alpha reduced form) likely prolongs the active half-life.3 Halotestin is known to be very androgenic and quite toxic to the liver. This steroid is rumored to be good in a ‘cutting stack’ because it seems to not put on much weight, but keeps a physique hard and increases aggression to get through workouts on low calories. Some evidence suggests that halotestin is a potent glucocorticoid antagonist. Like oxandrolone, halotestin actually increases total and free cortisol levels, while slightly reducing corticosteroid binding globulin (CBG) levels.4 CBG is a binding protein similar to sex hormone binding globulin (SHBG) that removes corticosteroids (like cortisol) from the blood and acts as a reservoir to resupply the blood if cortisol levels fall. Small changes in CBG levels can dramatically alter free plasma levels of cortisol. Obviously the effects of halotestin on glucocorticoid signaling are quite complicated and difficult to dissect. In any case, the likely scenario is that halotestin is anticatabolic with strong androgenic activity.

      Halotestin binds somewhat weakly to SHBG, but is still capable of displacing estradiol and testosterone at higher doses.1,5,6 The strong androgenic activity and lack of aromatization to estrogenic metabolites can result in reductions in plasma levels of SHBG, which may result in estrogenic side effects due to higher free levels of estrogens.7 Additionally, halotestin has a rather large suppressive effect on thyroid binding globulin levels, with only moderate compensatory increases in thyroxine-binding prealbumin which is likely to cause higher plasma levels of T4 and T3 with greater T3 uptake.4 These effects on thyroid hormones and binding proteins may help to explain the effectiveness of this drug in a “cutting” stack.

      Halotestin has been shown to be as effective as oxymetholone in elevating red blood cell levels in the scientific literature.8,9 Halotestin is available in the U.S. and in other countries, especially Mexico as a pharmaceutical preparation, as well as through black market suppliers. An interesting use of halotestin includes the use of a 5-alpha reductase inhibitor, like finasteride. The purpose of such a combination would be to harness the anticatabolic activity of halotestin, while reducing some of the harsher androgenic side effects.

      References:
      1. Saartok T, Dahlberg E, Gustafsson JA: Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Endocrinology, 1984;114(6):2100-6.
      2. Kammerer RC, Merdink JL, Jagels M, Catlin DH, Hui KK: Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry. J Steroid Biochem, 1990;36(6):659-66.
      3. Capponi VJ, Cox SR, Harrington EL, Wright CE, Antal EJ, Albert KS. Liquid chromatographic assay for fluoxymesterone in human serum with application to a preliminary bioavailability study. J Pharm Sci, 1985;74(3):308-11.
      4. Barbosa J, Seal US, Doe RP: Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol. J Clin Endocrinol Metab, 1971;32(2):232-40.
      5. Pugeat MM, Dunn JF, Nisula BC: Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab, 1981;53(1):69-75.
      6. Vigersky RA, Easley RB, Loriaux DL. Effect of fluoxymesterone on the pituitary-gonadal axis: the role of testosterone-estradiol-binding globulin. J Clin Endocrinol Metab, 1976;43(1):1-9.
      7. Wasserman P, Segal-Maurer S, Rubin D. Low sex hormone-binding globulin and testosterone levels in association with erectile dysfunction among human immunodeficiency virus-infected men receiving testosterone and oxandrolone. J Sex Med, 2008;5(1):241-7.
      8. Paulo LG, Fink GD, Roh BL, Fisher JW. Effects of several androgens and steroid metabolites on erythropoietin production in the isolated perfused dog kidney. Blood, 1974;43(1):39-47.
      9. Alexanian R. Erythropoietin and erythropoiesis in anemic man following androgens. Blood, 1969;33(4):564-72.

      Seth Roberts is a former pharmaceutical research scientist with over 10 years of pharmacological research in the discovery and development of novel therapeutics. Seth’s new book ANABOLIC PHARMACOLOGY is available now at www.LGSciences.com and www.NutraPlanet.com. [ Seth Roberts, 2009. All rights reserved. For informational purposes only, not to be considered as medical advice or an endorsement of the use of illegal substances.]

      Comment


      • #4
        so mr. seth i have a topic of much debate that i can never find answered well, and it is bridging, what do you think about it, if it is to be used, what are the best ways to do it, what length, and what aas to use, if no using hgh
        What we do in life echoes in eternity.

        Comment


        • #5
          Seth,

          Will oral turinabol or clenbuterol make you lose your hair? If so, how much would you have to take and for how long would you have to stay on for hair loss to take place? Thanks.

          Comment


          • #6
            Welcome Seth!

            Comment


            • #7
              Originally posted by peytonchris View Post
              so mr. seth i have a topic of much debate that i can never find answered well, and it is bridging, what do you think about it, if it is to be used, what are the best ways to do it, what length, and what aas to use, if no using hgh
              I am not a big fan of bridging. If you are going to be on, then be on -- if you want to be off then be off. That being said, I believe that longer more moderately dosed cycles are better for building muscle.

              If I were to bridge, then I would probably do so with a low dose of test over the course of 6 to 8 weeks.
              ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

              Comment


              • #8
                Originally posted by demo View Post
                Seth,

                Will oral turinabol or clenbuterol make you lose your hair? If so, how much would you have to take and for how long would you have to stay on for hair loss to take place? Thanks.
                Hair loss is a very personal topic since much of it is governed by genetic predisposition. If you are prone to hair loss then turinabol may accelerate it -- it is unlikely that clen would. N oone will be able to tell you a dose and duration that would not cause hair loss since no one knows your susceptibility.
                ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

                Comment


                • #9
                  How do you respond when someone young that is 18 years old that wants to began to pursue a career as a ifbb pro. At what age would you advise anabolics for someone young? also is there such thing as best steroids etc?

                  Comment


                  • #10
                    Originally posted by jj2006 View Post
                    How do you respond when someone young that is 18 years old that wants to began to pursue a career as a ifbb pro. At what age would you advise anabolics for someone young? also is there such thing as best steroids etc?
                    The reward would have to outweigh the risk. The rewards of a pro bodybuilding career or the possibility thereof compared to the risk of the drug use needed is not something I would justify -- especially as a teen.

                    If my kid had a very real chance at a pro football or baseball career worth millions and could use AAS under a doctors supervision then it may be worth the risk.

                    With bodybuilding, part of the problem is that you generally don't know what you have until you use the drugs -- look at some of the pros as teens. You may spend years using drugs to find out that you have a physique that is not going to get you a pro career that will make you any money.

                    With other sports you generally know if you are gifted before you touch a drug.
                    ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

                    Comment


                    • #11
                      mr. seth, i have a question about recovery time off cycle, i know that each person is different, but what is the reasonable difference in recovery for a 10 wk. cycle, and a 20 wk. cycle, if you are totally shutdown on both, i know that people usually use the same pct. time, so is the 20 wks. a "worse" shutdown? thanks
                      What we do in life echoes in eternity.

                      Comment


                      • #12
                        Originally posted by peytonchris View Post
                        mr. seth, i have a question about recovery time off cycle, i know that each person is different, but what is the reasonable difference in recovery for a 10 wk. cycle, and a 20 wk. cycle, if you are totally shutdown on both, i know that people usually use the same pct. time, so is the 20 wks. a "worse" shutdown? thanks
                        There really is no way to tell. It could depend largely on the AAS used during the cycle. You are also assuming recovery only involves natural testosterone production. There are other things that need to recover after a cycle such as the adrenal glands and any changes to receptor sensitivity over the course of a cycle. The recovery of natural tesosterone production after a 10 week cycle may not be very much different from that of a 20 week cycle (or it may be) but there is likely to be a large difference in the recovery of these other systems.
                        ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

                        Comment


                        • #13
                          ahah, nice response, this is very true, receptor sensitivity is another question too, but i have heard of many people that stay on and constantly grow without resorting to abnormal dosage, but i guess it could help to trade out between anabolics such as eq traded out with things like deca and tren to keep the body gaining as far as additions to test
                          What we do in life echoes in eternity.

                          Comment


                          • #14
                            Mr. Seth, let me see if I can put this into words for you and others to understand. Why do guys try to get more advances every go around with a cycle? Does you body get "adapted" to certain drugs, so the need to see optimal gains is to switch it up? Also, you hear a lot of people say, if it syour first cycle, use test only....why is this?

                            Comment


                            • #15
                              Originally posted by JCLadson View Post
                              Mr. Seth, let me see if I can put this into words for you and others to understand. Why do guys try to get more advances every go around with a cycle? Does you body get "adapted" to certain drugs, so the need to see optimal gains is to switch it up? Also, you hear a lot of people say, if it syour first cycle, use test only....why is this?
                              That is what is referred to as Bro-lore. It is people repeating things that they have heard in order to make themselves seem knowledgable eventhough it may not be very factual. The goal with each cyce isto get bigger. The body does not adapt to any certain drug but is trying to maintain an equilibrium. The body does not necessarily want to carry around all of this "extra" muscle so the rate of catabolism will increase. Also, there may be changes in receptor sensitivity or set-point of cortisol production that may require a person to increase doses over time. Also, most drugs are dosed on a body weight basis and as you increase your bodyweight, a higher dose will be needed to elicit the same response.
                              ANABOLIC PHARMACOLOGY is on sale at PrimordialPerformance.com - Friend me on Facebook

                              Comment

                              Working...
                              X