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  • Superdrol~Methyldrostanolone

    Superdrol/Methyldrostanolone

    Androgenic Rating = 20

    Anabolic Rating = 400

    Chemical Name = 2a,17a-dimethyl-5a-androstane-17b-ol-3-one

    Estrogenic Activity = none

    Progestational Activity = no data available

    Methyldrostanolone, also known as methasteron, is a potent oral anabolic steroid that was never sold as a prescription drug. In structure, this steroid is a close derivative of drostanolone (Masteron). The only difference in this case is the addition of a c-17 alpha methyl group, a modification that gives this steroid high oral bioavailability. The two agents remain very comparable, however. Both methyldrostanolone and drostanolone are non-aromatizable, so there is no difference in the estrogenicity of these two steroids, and both steroids retain favorable anabolic to androgenic ratios. Lab assays do put Superdrol ahead here, however, showing it to possess 4 times the anabolic potency of oral methyltestosterone while displaying only 20% of the androgenicity (a 20:1 ratio, compared to 3:1). The exact real-world relevance of these figures remains to be seen, however. Methyldrostanolone is favored by athletes for its moderate anabolic properties, which are usually accompanied by fat loss and minimal androgenic side effects.

    History:

    Methyldrostanolone was first described in 1959. This steroid was developed by the international pharmaceuticals giant Syntex, alongside such other well known anabolic agents as drostanolone propionate and Oxymetholone. Unlike drostanolone and oxymetholone, however, this steroid (at least in its basic form) was never released as a medicinal product. It was only sold for a brief period of time as a modified hormone called dimethazine. Dimethazine is made from two molecules of Methyldrostanolone that are bonded together, which are later metabolically separated to yield free Methyldrostanolone.

    So while technically Methyldrostanolone itself was never sold as a prescription agent, we can say that the drug was one utilized medicinally.OtherWise, the methyldrostanolone molecule Methyldrostanolone remained an obscure research steroid only, and was never itself approved for use in humans. Methyldrostanolone was released in early 2005 as an over the counter "grey market" anabolic steroid in the United States.

    The drug was being sold without restrictions as a nutritional supplement product, barring some minimum age disclaimers by the manufacturer. No State or Federal laws identify this drug as an anabolic steroid, which remove the legalities associated with being a Class III controlled substance like other steroids. This is simply due to the fact that methyldrostanolone was not in commerce at the time such laws were written, and was unknown to lawmakers. It was never legal to sell as a dietary supplement, however, and in late 2005 the FDA angrily acknowledged methyldrostanolone was being sold on the sports supplement market. In early 2006, the FDA sent letters to the manufacturer and a distributor demanding it be pulled from commerce. Superdrol has since been discontinued.

    Structural Characteristics:

    Methyldrostanolone is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, and 2) the introduction of a methyl group at carbon-2 (alpha), which considerably increases the anabolic strength of the steroid by heightening its resistance to metabolism by the 3-hydroxysteroid dehydrogenase enzyme in skeletal muscle tissue.

    Side Effects (Estrogenic):

    Methyldrostanolone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, methyldrostanolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.

    Administration (Men):

    Methydrostanolone was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage of methyldrostanolone for physique or performance-enhancing purposes seems to begin in the range of 10-20 mg per day, taken for no longer than 6 or 8 weeks. At this level it seems to impart a measurable muscle-building effect, which is usually accompanied by fat loss and increased definition. Don't expect to gain 30 pounds on this agent (its name, which is short for "Super Anadrol" is more marketing than reality), but many do walk away with more than 10 pounds of solid muscle gain when using this agent alone. In determining an optimal daily dosage, some do find the drug to be measurably more effective when venturing up to the 30 mg range. Potential hepatotoxicity should definitely be taken into account with such use, however.

    To avoid further escalating liver strain, 20 mg daily of daily of methyldrostanolone is sometimes stacked with a non-toxic injectable steroid, such as testosterone for mass-building phases of training, or nandrolone or boldenone for more lean tissue gain and definition, instead of simply increasing the dosage.The drug also works well in cutting cycles,where its lack of estrogenicity is highly favored. Often it is combined here with a non-aromatizable Injectable steroid like Primobolan or Parabolan.

    Administration (Women):

    Methyldrostanolone was never approved for use in humans. Prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage would fall around 2.5 mg per day, taken in cycles lasting no more fhan 4-6 weeks to minimize the chance for virilization. The main point of contention with females is probably going to be the 10 mg per capsule dosage, which is far too high to use. Application would require opening each capsule and splitting the powdered contents up into 4 separate doses. As with all steroids, virilization is still possible.

    Availability:

    Superdrol is no longer commercially produced, although some clone products may still be located.

    William Llewellyn Anabolics 2009.
    All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.


  • #2
    Methyldrostanolone (Superdrol)

    By Jason Rowland


    Chemical Name(s):

    2a,17a-dimethyl-5a-androst-3-one-17b-ol
    2a,17a-dimethyl-etiocholan-3-one-17b-ol


    Chemical Formula: C21H34O2
    Molecular Weight: 318
    CAS: NA
    Q Qatio: 20
    Anabolic #: 400
    Androgenic #: 20
    Oral Bioavailability: Estimated at 50%
    AR Binding Affinity: NA
    SHBG Binding Affinity: High
    Half Life: ~8 hours
    Legal Status (US): Not listed as a controlled substance
    Average Dose:
    10-30mg/day standalone
    5-10mg/day when stacked



    Characteristics

    Methyldrostanolone is a C-17 alpha alkylated steroid, originally developed by the American pharmaceutical company Syntex. This steroid is already active and does not require conversion. Methyldrostanolone is the 17aa version of the injectable steroid drostanolone (Masteron). This extra methylation makes this steroid about 3-4x more anabolic than Masteron, and slightly more anabolic than oxandrolone (Anavar). Due to the dimethylation, the toxicity of methyldrostanolone is greater than most other oral steroids. There have been many reported cases of heptatoxicity with this compound. (1-3)

    Despite the fact that methyldrostanolone is a DHT derivative and cannot convert to estrogen, some users have still reported gyno like symptoms during or after a cycle. This effect is likely related to the strong SHBG binding effect and increase in freely circulating estrogen (and testosterone) from SHBG. Gyno symptoms may also be related to the fact that methldrostanolone lacks a strong DHT metabolite to antagonize the effects of estrogen (while also having a relatively low intrinsic androgenic value).

    Having a fairly low androgenic value will mean that methyldrostanolone will be light on the hairline for most men. However those susceptible to male pattern baldness may still noticed accelerated hair loss during a cycle.

    Because of the di-methylation, methlydrostanolone is considerably more resistant to breakdown, thus more potent per mg than most other steroids. However this makes it more liver toxic than other single methylated 17aa orals. Negative effects on the liver generally manifest as a condition known as reversible cholestasis. This is essentially a slowing or complete blockage of bile acids from the liver. Immediate signs of compromised liver function included reduced appetite and general sickness, which will soon be accompanied by yellowing of the eyes (jaundice), excessive itchiness and very dark urine. If these effects are noticed, methyldrostanolone should be discontinued immediately.

    Because the effects on the liver it is very important to use a liver protecting supplement during any methyldrostanolone cycle. If not using a supplement to protect your liver, methyldrostanolone should never be used any longer than 2 weeks, with a maximum cycle length of 4 weeks with liver protection.

    Other reversible side effects from methyldrostanolone may include increased blood pressure, reduced HDL cholesterol and lower back pumps.

    Results wise, users should expect extreme strength increases and weight gain in a relatively short 2-4 week period. Weight gain upwards of 20lbs in 4 weeks is not unheard of with this incredibly potent compound. Although subcutaneous water gain would be minimal, intramuscular water retention should be expected. This is due to inhibition of 11b-hydroxylase and build-up of mineralcorticoids which encourage salt and water retention within the muscles. The most obvious physical effects will be improved vascularity, aggressive muscular pumps, and oily skin.

    While methyldrostanolone can stack well with most other steroids, it should never be stacked with another methylated (17aa) steroid.

    Common Clones:

    Superdrone by Primordial Performance
    Oxodrol 12 by IDS
    Superdrol by Anabolic Xtreme
    M-Drol byCompetitive Edge Labs (CEL)
    SD-1 by Performance Design
    Methyl VOL by Engineered Sports Technology (EST)
    Revenge SDX by Bioscience Technologies
    S-Drol by Nutracoastal
    E-Pol by Purus Labs
    MethaDROL by IForce
    Straight-DROL by Black China Labs
    MethylDX3 by Physical Enhancing Industries
    Oxevol (same as Dianevol) by Evolution Labs
    Beastdrol by Mrsupps

    References

    Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol.
    Beata Jasiurkowski MD, et al.
    The American Journal of Gastroenterology (2006) 101, 2659-2662;
    Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol (Methasteron): A Case Report and Literature Review
    John Nasr and Jawad Ahmad
    Digestive Diseases and Sciences
    Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases”
    Neeral L. et al.
    Clinical Gastroenterology and Hepatology, Volume 6, Issue 2, February 2008, Pages 255-258
    Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes”
    Julie Gauthier, Danielle Goudreault, Donald Poirier and Christiane Ayotte
    Steroids; Volume 74, Issue 3, March 2009, Pages 306-314
    All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

    Comment


    • #3
      Methasterone

      From Wikipedia, the free encyclopedia



      Systematic
      (IUPAC) name17β-Hydroxy-2α,17α-dimethyl-5α-androstane-3-one

      Identifiers
      CAS number 3381-88-2
      ATC code None

      Chemical data
      Formula C21H34O2
      Mol. mass 318.492 g/mol
      SMILES eMolecules & PubChem
      Synonyms Superdrol, methyldrostanolone

      Therapeutic considerations
      Pregnancy cat. ?
      Legal status
      Routes Oral

      Methasterone (Superdrol, methasteron, and methyldrostanolone) is an oral anabolic steroid that was never marketed through legitimate channels for medicinal purposes. It was brought to market, instead, in a clandestine fashion as a "designer steroid.”


      The synthesis of methasterone is first mentioned in the literature in 1956 in connection with research conducted by Syntex Corporation in order to discover a compound with anti-tumor properties.[1] This initial mention is elaborated upon in a 1959 research journal article, where its method of synthesis is discussed in greater detail, its tumor inhibiting properties are verified, and it is noted as being a “potent orally active anabolic agent exhibiting only weak androgenic activity.”[2] The results of subsequent assays to determine methasterone’s anabolic and androgenic activity were published in Vida’s Androgens and Anabolic Agents, a dated but still standard reference, where it was noted that methasterone possessed the oral bioavailability of methyl-testosterone while being 400% as anabolic and 20% as androgenic, yielding a Q-ratio (also known as an anabolic to androgenic ratio) of 20, which is considered very high.[3]

      Injectable counterpart

      Methasterone was never made a commercially available prescription drug. Instead, its injectable (non-17α-alkylated) counterpart, 2α-methyl-17β-hydroxy-5α-androstan-3-one, was introduced into commerce by its manufacturer Syntex Corporation as Masteron (chemical name drostanolone), the same company that brought Anadrol (oxymethalone) to market.[4]

      "Designer steroid"

      Methasterone resurfaced in 2005 as a “designer steroid”.[5] It was brought to market by Anabolic Xtreme as the primary ingredient of a dietary supplement named Superdrol. Its introduction into commerce may have represented an attempted circumvention of the 1990 Anabolic Steroid Control Act (along with its 2004 revision), since the law is, in part, drug-specific;[6] methasterone, as is the case with many designer steroids, was not declared a Schedule III class anabolic steroid in that act because it was not commercially available at the time the act, and its subsequent revision, were signed into law.[7] Methasterone was therefore being sold as an over-the-counter dietary supplement.

      Controversy and FDA involvement

      It was in late 2005 that the status of methasterone (Superdrol), in addition to that of four other designer steroids, as a genuine anabolic steroid was brought to public awareness by an article published in the Washington Post.[8] Don Catlin of the UCLA Olympic Laboratory, who conducted the studies, noted methasterone’s similarity to drostanolone. A warning by the FDA was issued soon after to the general public as well as to the distributor, Designer Supplements LLC, for the marketing of this compound.[9] Methasterone was subsequently added to the World Anti-Doping Agency’s list of prohibited substances in sport.[10]

      Anabolic efficacy

      The anabolic efficacy of this compound can be attested to anecdotally on the many forums online where anabolic drug use practices are openly discussed, as can its hepatoxicity (toxicity to the liver). Many cases of liver damage due to the use of methasterone have been cited in the medical literature.[11] [12] [13] [14] Although the original manufacturer ceased production in the face of possible governmental action, methasterone remains commercially available through over the counter dietary supplement products sometimes referred to as “Superdrol clones” and through domestic or foreign chemical production companies.

      References
      • ^ H. J. Ringold and G. Rosenkranz. “Steroids. LXXXIII. Synthesis of 2-Methyl and 2,2-Dimethyl Hormone Analogs.” Journal of Organic Chemistry. 21. (1956): 1333.
      • ^ Ringold, H. J., E. Batres, O. Halpern, and E. Necoechea. Journal of the American Chemical Society. “Steroids. CV.1 2-Methyl and 2-Hydroxymethylene-androstane Derivatives.” 81 (2). (1959): 427-432.
      • ^ Julius A. Vida. Androgens and Anabolic Agents: Chemistry and Pharmacology. New York: Academic Press, 1969. 23 & 168.
      • ^ “Superdrol, masteron en oxy komen uit hetzelfde nest” [Superdrol, Masteron, and Oxy come from the same nest]. Ergogenics.org. Accessed February 2009. http://www.ergogenics.org/157.html
      • ^ Van Enoo, Peter and Frans T. Delbeke. “Metabolism and excretion of anabolic steroids in doping control—New steroids and new insights.” Journal of Steroid Biochemistry & Molecular Biology. 101 (2006): 173.
      • ^ Office of Divesion Control, Drug Enforcement Administration, Department of Justice. “Implementation of the Anabolic Steroid Control Act of 2004.” Accessed February 2009. http://www.deadiversion.usdoj.gov/fed_regs/rules/2005/fr1216.htm
      • ^ Shipley, Amy, Bonnie Berkowitz and Christina Rivero. “Designer Steroids Hide and Seek.” The Washington Post. October 18, 2005. Accessed February 2009. http://www.washingtonpost.com/wp-dyn/content/graphic/2005/10/18/GR2005101800648.html
      • ^ Amy Shipley. “Steroids Detected in Dietary Tablets.” The Washington Post. November 30, 2005. Accessed February 2009. http://www.washingtonpost.com/wp-dyn/content/article/2005/11/29/AR2005112901636.html
      • ^ U.S. Food and Drug Administration. “FDA Warns Manufacturers About Illegal Steroid Products Sold as Dietary Supplements” [Press Release]. March 9, 2006. Accessed February 2009. http://www.fda.gov/bbs/topics/NEWS/2006/NEW01332.html
      • ^ World Anti-Doping Agency. “The World Anti-Doping Code: The 2009 Prohibited List: International Standard.” Accessed February 2009. http://www.wada-ama.org/rtecontent/document/2009_Prohibited_List_ENG_Final_20_Sept_08.pdf
      • ^ Jasiurkowski, Beata, Jaya Raj, David Wisinger, Richard Carlson, Lixian Zou, and Abdul Nadir. “Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol.” American Journal of Gastroenterology. 101.11 (2006): 2659-2662.
      • ^ Nasr, John and Jawad Ahmad. “Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol (Methasteron): A Case Report and Literature Review.” Digestive Diseases and Sciences. 10.1007 (2008).
      • ^ L. Shah, Neeral, Isabel Zacharias, Urmila Khettry, Nezam Afdhal, and Fredric D. Gordon.” Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases.” Clinical Gastroenterology and Hepatology. 6.2 (2008): 255-258.
      • ^ Singh V, Rudraraju M, Carey EJ, Byrne TJ, Vargas HE, Williams JE, Balan V, Douglas DD, Rakela J. “Severe Hepatotoxicity Caused by a Methasteron-containing, Performance-enhancing Supplement.” Journal of Clinical Gastroenterology. Volume 43, Number 3, March (2009).
      All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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