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Nandrolone (Deca) its effects explored

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  • Nandrolone (Deca) its effects explored

    Much debate has arisen over the effects of Nandrolone. I am starting this thread to provide multiple scientific studies on those effects to help us understand this popular compound.



    Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones.

    Hassager C, Jensen LT, Pødenphant J, Riis BJ, Christiansen C.

    Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.

    The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.
    http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract

    Here is an interesting one on bone mass;

    Nandrolone decanoate for men with osteoporosis.

    Hamdy RC, Moore SW, Whalen KE, Landy C.
    James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN USA.
    To compare the efficacy and safety of nandrolone decanoate and calcium (NDC) with those of calcium alone (CAL) in men with idiopathic osteoporosis, a 12-month, randomized, prospective, controlled study, was performed in an outpatient clinic. Twenty-one men with idiopathic osteoporosis (as determined by radiological and dual energy x-ray absorptiometry findings) were randomly allocated to either 50 mg nandrolone decanoate intramuscularly (im) weekly and 1,000 mg oral calcium carbonate daily (NDC group) or to 1,000 mg oral calcium carbonate daily (CAL group). Bone densitometry (total body, left femur, and lumbar spine), serum, and urine biochemical parameters were measured at 3-month intervals. In the NDC group, bone mineral density initially increased, reached a plateau, and then decreased to near baseline levels at 12 months. Increases in lean muscle mass mirrored these changes. Free and total testosterone significantly decreased. Hemoglobin increased in all patients in this group. Patients in the CAL group exhibited no significant change in either total body or bone mineral density or biochemical parameters. Thus, nandrolone decanoate, 50 mg im weekly, transiently increases the bone mass of men with idiopathic osteoporosis in this preliminary study. Careful monitoring is necessary.
    PMID: 10099043 [PubMed - indexed for MEDLINE]

    http://www.ncbi.nlm.nih.gov/pubmed/10099043
    All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.


  • #2
    Our own MD advocates low dose Nandrolone;

    http://www.musculardevelopment.com/c.../view/532/116/



    This one is interesting since this is exactly my experience with my rotator cuff.

    Nandrolone Decanoate and Load Increase Remodeling and Strength in Human Supraspinatus Bioartificial Tendons



    Ioannis K. Triantafillopoulos, MD*,, Albert J. Banes, PhD,,, Karl F. Bowman, Jr||, Melissa Maloney, MS¶, William E. Garrett, Jr, MD, PhD# and Spero G. Karas, MD*,,**



    From * the Shoulder and Elbow Service, University of North Carolina, Chapel Hill, North Carolina, Department of Orthopaedics, University of North Carolina, Chapel Hill, North Carolina, Flexcell International Corporation, Hillsborough, North Carolina, the Department of Biomedical Engineering, the || School of Medicine, University of North Carolina, Chapel Hill, North Carolina, ¶ Flexcell International Corporation, Hillsborough, North Carolina, and the # Department of Orthopaedics, Duke University, Durham, North Carolina

    ** Address correspondence to Spero G. Karas, MD, Chief, Shoulder and Elbow Service, University of North Carolina, Department of Orthopaedics, CB#7055, Chapel Hill, NC 27599-7055 (e-mail: [email protected] ).



    Background: To date, no studies document the effect of anabolic steroids on rotator cuff tendons.

    Study Design: Controlled laboratory study.

    Hypothesis: Anabolic steroids enhance remodeling and improve the biomechanical properties of bioartificially engineered human supraspinatus tendons.

    Methods: Bioartificial tendons were treated with either nandrolone decanoate (nonload, steroid, n = 18), loading (load, nonsteroid, n = 18), or both (load, steroid, n = 18). A control group received no treatment (nonload, nonsteroid [NLNS], n = 18). Bioartificial tendons’ remodeling was assessed by daily scanning, cytoskeletal organization by staining, matrix metalloproteinase–3 levels by ELISA assay, and biomechanical properties by load-to-failure testing.

    Results: The load, steroid group showed the greatest remodeling and the best organized actin cytoskeleton. Matrix metallo-proteinase–3 levels in the load, steroid group were greater than those of the nonload, nonsteroid group (P < .05). Ultimate stress and ultimate strain in the load, steroid group were greater than those of the nonload, nonsteroid and nonload, steroid groups (P < .05). The strain energy density in the load, steroid group was greater when compared to other groups (P < .05).

    Conclusions: Nandrolone decanoate and load acted synergistically to increase matrix remodeling and biomechanical properties of bioartificial tendons. Clinical Relevance: Data suggest anabolic steroids may enhance production of bioartificial tendons and rotator cuff tendon healing in vitro. More research is necessary before such clinical use is recommended.



    http://ajs.sagepub.com/cgi/content/abstract/32/4/934



    http://www.paktribune.com/news/print.php?id=183128
    All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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    • #3
      2 popular esters of Nandrolone and their effects on plasma concentrations in different muscle groups.

      This study compared the pharmacokinetics and pharmacodynamics of two currently available esters of nandrolone, the decanoate and phenylpropionate, as well as the influence of i.m. injection sites (gluteal vs. deltoid) and injection volumes (4 ml vs. 1 ml). In addition to measuring plasma nandrolone to investigate pharmacokinetics, we measured plasma testosterone and inhibin by radioimmunoassay to determine the pharmacodynamic effects of nandrolone-induced inhibition of pituitary gonadotrophin secretion, as reflected in LH-dependent Leydig (testosterone) and FSH-dependent Sertoli (inhibin) cell function in healthy men. We analyzed these data using an indirect pharmacodynamic response model, which has demonstrated, for the first time, prominent pharmacological differences between esters differing in only a single carbon in the side-chain, as well as systematic differences attributable to injection site and volume in humans.

      Fig. 1. Time course of plasma nandrolone concentrations in 23 healthy men over 32 days after i.m. injection of 100 mg of nandrolone phenylpropionate in 4 ml of arachis oil vehicle into the gluteal muscle (group 1) () or injection of 100 mg of nandrolone decanoate into the gluteal muscle in 4 ml of arachis oil vehicle (group 2) (), into the gluteal muscle in 1 ml of arachis oil vehicle (group 3) () or into the deltoid muscle in 1 ml of arachis oil vehicle (group 4) (). Results are expressed as mean and S.E.M., unless the S.E. is smaller than symbol.

      An amazing effect shown in this study was NPP kept blood plasma levels fairly high for 3-4 days meaning that every day injections are not needed as commonly thought.

      http://jpet.aspetjournals.org/cgi/content/full/281/1/93
      Attached Files
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      • #4
        Effects of Pharmacological Doses of Nandrolone Decanoate and Progressive Resistance Training in Immunodeficient Patients Infected with Human Immunodeficiency Virus
        Fred R. Sattler, S. Victoria Jaque, E. Todd Schroeder, Connie Olson, Michael P. Dube, Carmen Martinez, William Briggs, Richard Horton and Stanley Azen
        Department of Medicine, Division of Infectious Diseases (F.R.S., C.O., M.P.D.) and Endocrinology (C.M., R.H.), Department of Biokinesiology and Physical Therapy (S.V.J., E.T.S.), and Department of Preventive Medicine (S.A.), University of Southern California School of Medicine, Los Angeles County-University of Southern California Medical Center, Los Angeles, California 90033

        Address all correspondence and requests for reprints to: Dr. Fred R. Sattler, Los Angeles County-University of Southern California Medical Center, 1300 North Mission Road, Los Angeles, California 90033.


        Abstract



        This nonplacebo-controlled, open label, randomized study was conducted to test the hypotheses that pharmacological doses of nandrolone decanoate would increase lean body tissue, muscle mass, and strength in immunodeficient human immunodeficiency virus-infected men, and that these effects would be enhanced with progressive resistance training (PRT). Thirty human immunodeficiency virus-positive men with fewer than 400 CD4 lymphocytes/mm3 were randomly assigned to receive weekly injections of nandrolone alone or in combination with supervised PRT at 80% of the one-repetition maximum three times weekly for 12 weeks. Total body weight increased significantly in both groups (3.2 ± 2.7 and 4.0 ± 2.0 kg, respectively; P < 0.001), with increases due primarily to augmentation of lean tissue. Lean body mass determined by dual energy x-ray absorptiometry increased significantly more in the PRT group (3.9 ± 2.3 vs. 5.2 ± 5.7 kg, respectively; P = 0.03). Body cell mass by bioelectrical impedance analysis increased significantly (P < 0.001) in both groups (2.6 ± 1.0 vs. 2.9 ± 0.8 kg), but to a similar magnitude (P = NS). Significant increases in cross-sectional area by magnetic resonance imaging of total thigh muscles (1538 ± 767 and 1480 ± 532 mm2), quadriceps (705 ± 365 and 717 ± 288 mm2), and hamstrings (842 ± 409 and 771 ± 295 mm2) occurred with both treatment strategies (P < 0.001 for the three muscle areas); these increases were similar in both groups (P = NS). By the one-repetition method, strength increased in both upper and lower body exercises, with gains ranging from 10.3–31% in the nandrolone group and from 14.4–53.0% in the PRT group (P < 0.006 with one exception). Gains in strength were of significantly greater magnitude in the PRT group (P 0.005 for all comparisons), even after correction for lean body mass. Thus, pharmacological doses of nandrolone decanoate yielded significant gains in total weight, lean body mass, body cell mass, muscle size, and strength. The increases in lean body mass and muscular strength were significantly augmented with PRT.



        Complete study;
        http://jcem.endojournals.org/cgi/content/full/84/4/1268
        All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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        • #5
          been on nandrolone for 4 weeks, joints still hurt >

          Comment


          • #6
            Originally posted by Reloaded View Post
            been on nandrolone for 4 weeks, joints still hurt >
            The first 2 studies were 1 year in duration. I have personally had significant reduction in pain after 1 month and complete reversal of injuries after 3-4 months.

            What is your dose of Nandrolone? Are you using any other suppliments like glucosimine or fish oil? Are you protecting your joints from further injury by modifying your training?
            All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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            • #7
              Intresting
              4500 calories

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              • #8
                Originally posted by Reloaded View Post
                been on nandrolone for 4 weeks, joints still hurt >
                Are you running Norma?

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                • #9
                  Don't know what norma is but I'm onn 300mg/wk I got off glucosamine and fish oil, I think ima get back on

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                  • #10
                    Originally posted by Reloaded View Post
                    Don't know what norma is but I'm onn 300mg/wk I got off glucosamine and fish oil, I think ima get back on
                    Anything to support joint health is advisable when lifting heavy poundages. I would also modify training if possible to keep from aggrevating an injury.
                    All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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                    • #11
                      deca is the best steroids in the world

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                      • #12
                        Originally posted by indoroids View Post
                        deca is the best steroids in the world

                        From what Ive read the Nandralone phenylpropionate is like a faster acting deca without the water retention. So maybe they are pretty close to both being the best.
                        Circumstances do not make a man, they reveal him.

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                        • #13
                          Originally posted by heavyiron View Post
                          The first 2 studies were 1 year in duration. I have personally had significant reduction in pain after 1 month and complete reversal of injuries after 3-4 months.

                          What is your dose of Nandrolone? Are you using any other suppliments like glucosimine or fish oil? Are you protecting your joints from further injury by modifying your training?
                          Do you think the deca has also helped you add muscle size other than what you may have attained by training without pain?

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                          • #14
                            Originally posted by Nemesis RR View Post
                            Do you think the deca has also helped you add muscle size other than what you may have attained by training without pain?
                            Deca will add size but not as much as test mg for mg. I always stack Deca with test so I don't need much Deca for performance. The rule of thumb for dosing Deca by itself for performance is 2mg per lb of body weight. I personally like sex so I would never use Deca alone as it decreases libido in almost everyone who takes it.
                            All posts are for entertainment and may contain fiction. Consult a doctor before using any medication.

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                            • #15
                              Joint Pain

                              If deca is being added to test cycle only for joint relief (without expectation of added mass), how many mgs/week? Is 200mg enough to gain the benefit? At 200mg/week, is prolactin production an issue? Would arimidex keep bloat down? I have some for test anyway . . . Finally, do you run Deca whole cycle or wait 4 weeks for test to kick? end with last shot of test??

                              I apologize in advance for my ignorance . . .

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