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Thread: Winstrol (Stanozolol) A Basic Guide By Heavyiron

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    Default Winstrol (Stanozolol) A Basic Guide By Heavyiron

    Winstrol (Stanozolol) A Basic Guide By Heavyiron

    Stanozolol has a anabolic rating of 320 and an androgenic rating of 30 making it an excellent steroid for promoting muscle growth with zero water retention. Stanozolol cannot aromatize into estrogen so estrogenic side effects like water retention are not a factor. Even the most gyno prone users can use Winstrol without any worry of gynocomastia.

    Winstrol is excellent for dieting bodybuilders and is best employed near the end of a cutting cycle to keep the user anabolic but give a dry shredded appearance. Winstrol is also favored by speed athletes like runners, swimmers and even fighters who want to stay in a certain weight class but want to have an anabolic edge.

    Winstrol also significantly lowers SHBG even at very low doses in a matter of a few days. This is significant because that equates to more free testosterone. Winstrol stacked with testosterone means more testosterone stays free or active. Some users report increased sex drive when stacking Winstrol with testosterone. Basically Winstrol makes your testosterone work better and it can raise libido.

    Administration Men

    A good starting dose for performance is 25-50mg Winstrol daily. I prefer to stack Winstrol with Testosterone Propionate. I also prefer shorter runs of around 3-6 weeks due to liver stress and Winstrol’s profound ability to lower HDL and raise LDL like most orals.

    Administration Women

    A good starting dose for performance is 10mg Winstrol daily for 6-8 weeks. A more adventuresome female may take up to 20mg daily however side effects will increase with dosage.

    Not all Winstrol is created equal

    Injectable Winstrol is a suspension as opposed to a solution. Suspensions have tiny particles that are visible with the naked eye. If left on the shelf for a few days many times the particles will sink to the bottom leaving the clear solvents and water on the top. Depending on the manufacturer, particle sizes vary meaning some Winstrol preparations can clog a 22 gauge needle. Ultra micronized Winstrol can easily pass through a 25 gauge needle making injections more comfortable.



    Can I mix water based Winstrol with oil based steroids?

    A common misconception is that oil and water based steroids cannot be injected together. This is absolutely false. You may mix water based Winstrol with any oil based steroid. The picture below is Cypionate and Winstrol together in the same syringe (Winny lava lamp).



    Bacteria and water based steroids (drinking your Winstrol)

    Bacteria have an easier time living in water based steroids than in oil based steroids. Winstrol is notorious for causing painful lumps at the injection site and for causing infections and or abscesses. This is because many underground labs improperly assemble steroids not because of the Winstrol itself. I don't recommend injecting UGL Winstrol due to the risk for infection unless it's a regulated lab. I only recommend human grade injectable Winstrol made at GMP standards.

    http://forums.musculardevelopment.co...(Graphic-Video)

    Because injectable Winstrol can be ingested orally and because it can cause infections when injected some users drink their injectable Winstrol to avoid infections as gastric acid destroys the bacteria. You may drink your Winstrol however injecting has been proven to work better mg for mg than oral administration. However, injectable Winstrol tastes absolutely awful.

    Overall Winstrol is an excellent cutting anabolic and also well suited for speed sports. It’s the “summer” steroid because it does not promote the watery look that so many other steroids do.



    ~heavyiron
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    Stimulation of collagen synthesis by the anabolic steroid stanozolol.

    Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A, Yamaguchi Y.
    University of Miami School of Medicine, Department of Dermatology, Miami Veterans Affairs Medical Center, Florida, USA.

    There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.

    PMID: 9856839 [PubMed - indexed for MEDLINE]
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    The effect of stanozolol on 15nitrogen retention in the dog.

    Olson ME, Morck DW, Quinn KB.
    Animal Health Unit and Gastrointestinal Sciences, University of Calgary, Alberta. molson@ucalgary.ca

    The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined. Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.

    PMID: 11041505 [PubMed - indexed for MEDLINE]
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    J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200.

    Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test.

    Sinnecker G, Köhler S.
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    Department of Pediatrics, University of Hamburg, West Germany.

    Abstract

    Both the androgen-induced decline in serum sex hormone-binding globulin (SHBG) levels during puberty and the anabolic effect of exogenous testosterone are absent in patients with androgen insensitivity (testicular feminization). To determine whether the androgen-induced decline in serum SHBG could be used as a test of androgen sensitivity, we studied the effect of the anabolic-androgenic steroid stanozolol (17 beta-hydroxy-17 alpha-methyl-5 alpha-androstano-[3,2-c]pyrazol) on serum SHBG in 25 control subjects, 3 patients with complete androgen insensitivity, and 4 patients with partial androgen insensitivity. Stanozolol was administered orally for 3 days (0.2 mg/kg.day); blood samples were taken before and 5, 6, 7, and 8 days after the beginning of the test for measurements of serum SHBG. The lowest value (i.e. the peak response) in each subject was used as the measure of the response to stanozolol. In the control subjects the mean nadir serum SHBG level was 51.6 +/- 5.9% (+/- SD) of the initial value (P less than 0.001). In the 4 patients with partial androgen insensitivity the nadir serum SHBG ranged from 73-89%, and in the 3 patients with complete androgen insensitivity it ranged from 93-97% of the initial value. Thus, the decrease in serum SHBG after short term administration of stanozolol reflects androgen responsiveness and, thus, may be used to differentiate patients with androgen insensitivity syndromes from those with other causes of male pseudohermaphroditism.

    PMID: 2723028 [PubMed - indexed for MEDLINE]
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    J Steroid Biochem Mol Biol. 2005 Apr;94(5):481-7. Epub 2005 Mar 17.

    Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study.

    Feldkoren BI, Andersson S.
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    Department of Obstetrics-Gynecology and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9032, USA.

    Abstract

    Anabolic steroids are synthetic derivatives of testosterone and are characterized by their ability to cause nitrogen retention and positive protein metabolism, thereby leading to increased protein synthesis and muscle mass. There are disagreements in the literature in regards to the interaction of anabolic steroids with the androgen receptor (AR) as revealed by competitive ligand binding assays in vitro using cytosolic preparations from prostate and skeletal muscle. By use of tissue extracts, it has been shown that some anabolic steroids have binding affinities for the AR that are higher than that of the natural androgen testosterone, while others such as stanozolol and methanedienone have significantly lower affinities as compared with testosterone. In this study we show that stanozolol and methanedienone are low affinity ligands of the rat recombinant AR as revealed by a ligand binding assay in vitro, however, based on a cell-based AR-dependent transactivation assay, they are potent activators of the AR. We also show that a single injection of stanozolol and methanedienone causes a rapid cytosolic depletion of AR in rat skeletal muscle. Based on these results, we conclude that anabolic steroids with low affinity to AR in vitro, can in fact in vivo act on the AR to cause biological responses.

    PMID: 15876413 [PubMed - indexed for MEDLINE]

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    Interesting...
    Thanks heavyiron

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