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Thread: Dianabol~(Methandrostenolone)

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    Super Moderator heavyiron's Avatar
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    Default Dianabol~(Methandrostenolone)

    Dianabol (Methandrostenolone)
    Dianabol

    Dbol - Methandrostenolone

    This was more or less the second Anabolic Steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900īs and experimented with by Naziīs in WW2, in an attempt to produce a better soldier.

    Russian Dianabol and Team Sports History

    Russian athletes in the 1953 World Championships as well as the Olympic games then used testosterone with great success. After that, John Zeigler, who was a doctor working with the US Weightlifting Team, began a cooperative project with Ciba to develop an equalizer for US atheletes. Flash forward to 1956 and enter Dianabol ; the original trade name for Cibaīs Methandrostenolone... but called "Dbol" by athletes. The original package insert said that 10mgs/day was enough to provide full androgen replacement for a man and Dr.Zeigler recommended that athletes take 5-10mgs/day. Incidentally, this is also the dose that Bodybuilders were reputed to take from then until roughly the 1970īs. Yeah, this was allegedly Arnoldīs dose, Zaneīs dose, etc... simply stacked with some testosterone. (For any trivia buffs out there, Dan Duchaineīs mail order steroid business operated under the name "The John Zeigler Fan Club").

    Dianabol Steroid Use

    Enough with the history lesson, lets get into what this stuff is, and what it does. Well, first off, itīs usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). It is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive itsī first pass through your liver, and make it into your blood stream. Itīll raise your blood pressure (4) and is also hepatoxic (Liver-Toxic), so be careful with it. Although I have known people to take up to 100mgs/day of this stuff and not suffer any ill-effects, and one study looked at that exact dose, and the people involved didnīt suffer any intolerable side effects ( 7). Lets examine this particular study a bit further, though:

    In this study, done in the early 80īs, a very high dose of Dbol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of itīs normal value, plasma GH went up about a third, LH dropped to about 80% of itīs original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Body fat did not go up significantly and Fat Free Mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that Dbol increases Fat Free Mass as well as increasing strength and performance. I can only agree, having found this to be the case for me when I did my first cycle (which was 6 weeks of dbol alone at 25mgs/day), I gained roughly 25lbs and kept nearly ― of it. Since then, Dbol has always had a special place in my heart.

    Dianabol Side Effects

    As with many other 17aa steroids, Dianabol is also a very weak binder to the Androgen Receptor, so most of itīs effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as indicated by the production of muscle tissue with very high levels of nitrogen, etc... which was indicated in the 100mg/day study). This also means it only has a modest aromatase activity (2).

    How strong is Dbol? Well...on a mg for mg basis, most people agree that itīs stronger than A50...but the reason most people donīt get the same gains off of Dbol is that almost nobody takes equivalent doses (I mean...Iīve heard of people taking 150mgs of A50, but not Dbol, even though the dbol would probably provide more solid gains and be less toxic, I suspect).

    So how do we incorporate this stuff into our AAS regimen? Clearly, the inclusion of Dbol at any point in a cycle would contribute to gains, however, Iīd speculate that Dbol is most regularly used for 2 reasons

    1. At the start of a cycle to "Kick Start" gains.
    2. As a "Bridge" between cycles, to maintain gains.

    Lets examine these two uses.

    Dianabol Cycle

    In order to kick start a dianabol cycle, usually what you do is incorporate a fast acting oral like dianabol (or anadrol) and combine it with long acting injectables (such as Deca or Eq with some Testosterone). The reasoning here is that the oral (Dbol in this case) will give almost immediate results, while the injectable takes time to produce results. The end result is that you start seeing results within the first week of your cycle and continue up until the end with the injectables. This entails taking anywhere from 25-50mgs of dbol (although as little as 20mgs or as much as 100mgs have been reported) for 3-6 weeks at the start of a cycle (average time for a "Kick Start" is 4 weeks, though), and then ceasing their use as the injectables start to produce results.

    In order to successfully bridge between cycles (and this means using a low dose of AAS, in this case dbol), you need to recover your natural hormonal levels to pre-cycle levels or to within acceptable parameters, and then you start your next cycle. The idea here is that you wonīt lose any gains, but rather a low dose of an AAS will help you maintain them. Typically, youīd use around 10mgs/day of dbol and combine it with an aggressive Post-Cycle Therapy (PCT) course of Nolvadex (and/or Clomid) and HCG. This would give you full androgen replacement from the Dbol and a shot at recovering your natural hormonal levels via the other stuff you are taking. Remember, the 100mg/day dose of dbol in the study we looked at earlier did not suppress Test, LH, or FSH to a degree that would make recovery impossible and certainly not with 1/10th that dose in conjunction with an aggressive PCT.

    All in all, this is a very good drug, and a potent tool for quick gains or retaining gains...when used properly and safely.

    Dbol Facts

    [17a-methyl-17b-hydroxy-1,4-androstadien-3-one]
    Molecular Weight: 300.44
    Formula: C20H28O2
    Melting Point: N/A
    Manufacturer: Ciba (originally)
    Release Date: 1956
    Effective dose: 25-50mgs (as low as 10 and as high as 100 have been reported)
    Active Life: 6-8hours
    Detection Time: up to 6 weeks
    Anabolic/Androgenic Ratio (Range): 90-210:40-60


    References:
    1. Serakovskii S, Matsīkoviak I., Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells, Farmakol Toksikol 1981 Mar-Apr;44(2):213-7
    2. Brain Res. 1998 May 11;792(2):271-6.
    3. Chemfinder. Copyright 2004 CambridgeSoft Corporation. Cambridge, MA, USA.
    4. Br Med J. 1975 May 31;2(5969):471-3.
    5. www.steroid.com
    6. http://www.*****************.com
    7. Clin Sci (Lond). 1981 Apr;60(4):457-61
    8. Steroids. 1984 Dec;44(6):485-95.
    9. Vrach Delo. 1983 Nov;(11):34-6. Russian
    10. Acta Med Acad Sci Hung. 1975;32(1):27-34
    11. 4 Nesterin MF, Budik VM, Narodetskaia RV, Solovīeva GI, Stoianova VG., Effect of methandrostenolone on liver morphology and enzymatic activity, Farmakol Toksikol 1980 Sep-Oct;43(5):597-601
    steroid.com
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    Super Moderator heavyiron's Avatar
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    The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area.

    Roselli CE.
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201-3098, USA. rosellic@ohsu.edu

    The level of aromatase in the preoptic area of rats is transcriptionally regulated through a specific androgen-receptor mediated mechanism and can be used as a measure of central androgenic effect. Therefore, several commonly abused anabolic-androgenic steroids (AAS) were tested for their ability to induce aromatase activity in the preoptic area of castrated rats. In addition, we determined the relative binding affinities of these compounds for the androgen receptor, as well as their ability to bind androgen receptor in vivo following subcutaneous injections. All of the AAS compounds tested significantly stimulated POA aromatase activity above castrate levels. The compounds that produced the greatest stimulation of aromatase activity were those that bound most avidly to the androgen receptor in vitro (i.e., testosterone, dihydrotestosterone and nandrolone). In contrast, the 17alpha-alkylated compounds that were tested (stanozolol, danazol, methandrostenolone) modestly stimulated aromatase and were weak competitors for the androgen receptor. The subcutaneous injection of AAS compounds increased the concentrations of occupied nuclear androgen receptors in the brain, but the magnitude of effect was not related to their potency for inducing aromatase or their relative binding affinity for the androgen receptor suggesting that androgen receptor occupancy in POA is not correlated with the action of androgen on aromatase. The present results help explain the behavioral effects of AAS compounds in rats. Copyright 1998 Elsevier Science B.V.

    PMID: 9593936 [PubMed - indexed for MEDLINE]
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    Super Moderator heavyiron's Avatar
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    Br J Pharmacol. 1999 Mar;126(6):1301-6.

    Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.

    Thiblin I, Finn A, Ross SB, Stenfors C.

    Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.

    Abstract

    1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone, methandrostenolone, and oxymetholone) on 5-hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems.

    full study

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565900/
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    Since dbol has an half life of 6-8 hrs would you split up doses?

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    Juggernaut ScarHead's Avatar
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    Quote Originally Posted by ONEDEEP0811 View Post
    Since dbol has an half life of 6-8 hrs would you split up doses?
    I split it up.

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    Or you can take it all in the morning.

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    Great read heavy. Very knowledgeable

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    Be aware the some people like myself are very lethargic on dbol and can't even get out of bed, never mind to the gym. I'm saving the rest of my dbol for my tren cycle to see if it helps with the insomnia before bed. The only euphoria I have gotten was from Phera and Halo was a close second, but dbol is a no go for me.

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    Quote Originally Posted by VickMD View Post
    Be aware the some people like myself are very lethargic on dbol and can't even get out of bed, never mind to the gym. I'm saving the rest of my dbol for my tren cycle to see if it helps with the insomnia before bed. The only euphoria I have gotten was from Phera and Halo was a close second, but dbol is a no go for me.
    This is very rare. Dbol is a huge energy booster for most. Am using it now @30mg/day and my intensity in the gym is like 10x.

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    Quote Originally Posted by the-unnatural View Post
    This is very rare. Dbol is a huge energy booster for most. Am using it now @30mg/day and my intensity in the gym is like 10x.
    But what about out of the gym? That's how SD and tren is for a lot of people. You tear it up in the gym but you're lethargic throughout the day.
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    Is the water retention the primary cause of lethargy Pantera? Or is it something else?
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    It sure as hell isn't water retention when it comes to sd or tren. From tren I believe it's mostly lack of sleep. If I take melatonin though I sleep fine and it's not an issue. Now sd is something else.... Broscience on my end, it's the harshness on your body. All orals are harsh on the body some more than others. People report lethargy from many orals. You just hear of it from sd all the time cause it's legal and therefore easy to get.
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    Is the tren sleep problem thing noted in every user or something some individuals experience? SD is by far the most potent oral out there, and tren would be one of the best aas out there, highly anabolic, but these compounds seem to be extremely harsh on the body.
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    I wouldn't say every. Everytime you do someone steps in with personal experience. But it seems to be the large majority for sure. Melatonin helps some, others have to take prescription sleep meds. Melatonin does woders for me on tren. I'll take it every night on tren and sleep fine. Sometimes I forget to take it and after a little while of lying in bed not getting sleepy I realize I forgot to take it. I do and then I start getting sleepy. You can chew it too for quick absorption (what I always did when I realized I forgot). It has basically no flavor.

    And yes the stronger steroids always have stronger sides. They go hand in hand. Don't expect to blow up on tren though. Some notice very little strength and weight gains from tren. Your look will change though for sure. Tren + sd.... =)
    PanterA is a fictional character for entertainment purposes only.

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    Behemoth the-unnatural's Avatar
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    Quote Originally Posted by PanterA View Post
    But what about out of the gym? That's how SD and tren is for a lot of people. You tear it up in the gym but you're lethargic throughout the day.
    In terms how I feel, its wonderful out of the gym. I feel completely normal. But I really need to start controlling my blood pressure.

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    Quote Originally Posted by PanterA View Post
    I wouldn't say every. Everytime you do someone steps in with personal experience. But it seems to be the large majority for sure. Melatonin helps some, others have to take prescription sleep meds. Melatonin does woders for me on tren. I'll take it every night on tren and sleep fine. Sometimes I forget to take it and after a little while of lying in bed not getting sleepy I realize I forgot to take it. I do and then I start getting sleepy. You can chew it too for quick absorption (what I always did when I realized I forgot). It has basically no flavor.

    And yes the stronger steroids always have stronger sides. They go hand in hand. Don't expect to blow up on tren though. Some notice very little strength and weight gains from tren. Your look will change though for sure. Tren + sd.... =)
    on my last cycle I ran tren, masterone and test p.....15mg melatonin, 3 zma, nyquil and weed even taken together at same time couldn't keep me asleep for more then a 2 hrs stretch for 8 weeks...bout every 12-14 days I would just sleep like 12 hrs straight cause body was shutting down due to lack of sleep....might be trying a script for sleep meds if it happens again...also tried flexoral and gravol and same resuslts......oh and it was the 7th time I have run tren in my life and first time I had sleep issues...and they sucked big time....

    still got to love how it makes you look though...just saying

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    Behemoth the-unnatural's Avatar
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    ^^^ what doses did you start tren with?

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